A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Combination of Cysteine and Glutathione Prevents Ethanol Induced Hangover and Liver Damage by Modulation of Nrf2 Signaling in HepG2 Cells and Mice Chronic Glutathione Depletion Confers Protection against Alcohol induced Steatosis: Implication for Redox Activation of AMP activated Protein Kinase Pathway Scientific Reports IV Therapy for Liver Disease Lone Star IV Medics